AANP Adult Gerontology Primary Care Nurse Practitioner Practice Exam 2025 – The All-in-One Resource to Ensure Exam Success!

The primary concern when coadministering sulfonamides with warfarin is the potential for an increased International Normalized Ratio (INR). Sulfonamides can inhibit the metabolism of warfarin in the liver, which may lead to an increase in warfarin's anticoagulant effects. As warfarin is a highly protein-bound medication, the displacement of warfarin from protein binding sites by sulfonamides can also elevate the levels of free warfarin in circulation, resulting in a higher INR. This heightened INR indicates a greater risk for bleeding complications, making it essential for healthcare providers to monitor the INR closely when these medications are used together.

Other options, while they describe possible effects or concerns associated with sulfonamide use, do not capture the primary critical interaction with warfarin management. Decreased effectiveness of warfarin is less likely, as sulfonamides tend to enhance the effects instead. The risk of kidney stones and photosensitivity are significant concerns with sulfonamides themselves but are not the primary issue in the context of their interaction with warfarin therapy. Thus, increased INR is the most relevant concern when managing patients on both medications.