AANP Adult Gerontology Primary Care Nurse Practitioner Practice Exam 2025 – The All-in-One Resource to Ensure Exam Success!

Question: 1 / 400

Which of the following medications belongs to the first generation of sulfonylureas?

Tolbutamide

The medication that belongs to the first generation of sulfonylureas is tolbutamide. First-generation sulfonylureas, including tolbutamide, were the first class of oral hypoglycemic agents developed to manage type 2 diabetes mellitus by stimulating insulin secretion from pancreatic beta-cells.

Other mentioned medications such as glipizide, glyburide, and glimepiride are classified as second-generation sulfonylureas. They were developed later and have a more potent effect and a different pharmacokinetic profile compared to first-generation agents, allowing for lower doses and fewer side effects.

Understanding this classification is crucial for proper medication management in patients with type 2 diabetes, as it informs not only the choice of medication but also implications for efficacy, safety, and drug interactions.

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Glipizide

Glyburide

Glimepiride

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