AANP Adult Gerontology Primary Care Nurse Practitioner Practice Exam 2025 – The All-in-One Resource to Ensure Exam Success!

Nateglinide is indicated for the management of postprandial hyperglycemia due to its mechanism of action as a rapid-acting insulin secretagogue. This medication stimulates the pancreas to release insulin in response to meals, which is particularly effective in lowering blood sugar levels that rise after eating. This characteristic makes it especially useful in controlling blood glucose spikes that can occur after meals, addressing the postprandial aspect of hyperglycemia.

In contrast, the other medications listed have different indications or mechanisms of action that do not specifically target postprandial blood glucose levels. Colesevelam is a bile acid sequestrant used primarily for lowering cholesterol levels and has a secondary role in diabetes management but is not as direct a treatment for postprandial hyperglycemia. Glimepiride, while it also stimulates insulin secretion like nateglinide, has a longer duration of action and is not specifically timed around meals to manage postprandial spikes. Pioglitazone works through improving insulin sensitivity and is primarily effective for fasting hyperglycemia rather than specifically targeting elevations in blood sugar that occur after meals. Thus, nateglinide is the most appropriate choice for addressing postprandial hyperglycemia.